{"id":517,"date":"2026-10-30T19:50:25","date_gmt":"2026-10-30T11:50:25","guid":{"rendered":"https:\/\/www.molbio.cn\/?page_id=517"},"modified":"2026-10-30T19:58:13","modified_gmt":"2026-10-30T11:58:13","slug":"%e5%a4%9a%e8%82%bd%e5%90%88%e6%88%90","status":"publish","type":"page","link":"https:\/\/www.molbio.cn\/?page_id=517","title":{"rendered":"\u591a\u80bd\u5408\u6210"},"content":{"rendered":"\t\t
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\u591a\u80bd\u5408\u6210<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u4e13\u6ce8\u9ad8\u54c1\u8d28\u591a\u80bd\u5b9a\u5236\u5408\u6210\uff0c\u63d0\u4f9b\u7cbe\u51c6\u5e8f\u5217\u8bbe\u8ba1\u3001\u8367\u5149\u6807\u8bb0\u3001\u73af\u80bd\u4fee\u9970\u53ca\u7eaf\u5316\u68c0\u6d4b\u670d\u52a1\uff0c\u52a9\u529b\u79d1\u7814\u521b\u65b0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\u591a\u80bd\u5408\u6210\uff1a\u6280\u672f\u539f\u7406<\/span>\u4e0e\u79d1\u7814\u5e94\u7528<\/span><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u591a\u80bd\u662f\u7531\u6c28\u57fa\u9178\u901a\u8fc7\u80bd\u952e\u8fde\u63a5\u5f62\u6210\u7684\u751f\u7269\u6d3b\u6027\u5206\u5b50\uff0c\u5728\u751f\u547d\u6d3b\u52a8\u8c03\u8282\u3001\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u3001\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u53ca\u751f\u7269\u533b\u5b66\u7814\u7a76\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u968f\u7740\u751f\u547d\u79d1\u5b66\u548c\u751f\u7269\u6280\u672f\u7684\u53d1\u5c55\uff0c\u591a\u80bd\u5df2\u6210\u4e3a\u57fa\u7840\u79d1\u7814\u3001\u836f\u7269\u7814\u53d1\u53ca\u5206\u5b50\u529f\u80fd\u7814\u7a76\u4e2d\u7684\u91cd\u8981\u5de5\u5177\u3002\u901a\u8fc7\u4eba\u5de5\u8bbe\u8ba1\u4e0e\u5316\u5b66\u5408\u6210\uff0c\u7814\u7a76\u4eba\u5458\u80fd\u591f\u83b7\u5f97\u5177\u6709\u7279\u5b9a\u6c28\u57fa\u9178\u5e8f\u5217\u548c\u7ed3\u6784\u7279\u5f81\u7684\u591a\u80bd\uff0c\u4ee5\u6ee1\u8db3\u4e0d\u540c\u79d1\u7814\u9879\u76ee\u7684\u9700\u6c42\u3002<\/p>

\u76ee\u524d\uff0c\u56fa\u76f8\u591a\u80bd\u5408\u6210\uff08Solid-Phase Peptide Synthesis\uff0cSPPS\uff09\u662f\u5e7f\u6cdb\u5e94\u7528\u7684\u591a\u80bd\u5236\u5907\u6280\u672f\u4e4b\u4e00\u3002\u8be5\u65b9\u6cd5\u4ee5\u56fa\u76f8\u6811\u8102\u4e3a\u8f7d\u4f53\uff0c\u901a\u8fc7\u53cd\u590d\u8fdb\u884c\u6c28\u57fa\u9178\u5076\u8054\u548c\u8131\u4fdd\u62a4\u53cd\u5e94\uff0c\u9010\u6b65\u8fde\u63a5\u6c28\u57fa\u9178\uff0c\u6700\u7ec8\u5f62\u6210\u76ee\u6807\u591a\u80bd\u3002\u5b8c\u6210\u5408\u6210\u540e\uff0c\u8fd8\u9700\u8981\u7ecf\u8fc7\u5207\u5272\u3001\u7eaf\u5316\u53ca\u8d28\u91cf\u68c0\u6d4b\u7b49\u73af\u8282\uff0c\u4ee5\u83b7\u5f97\u7b26\u5408\u8981\u6c42\u7684\u591a\u80bd\u4ea7\u54c1\u3002<\/p>

\u591a\u80bd\u5408\u6210\u7684\u8d28\u91cf\u4e0d\u4ec5\u53d6\u51b3\u4e8e\u5408\u6210\u5de5\u827a\uff0c\u8fd8\u4e0e\u5e8f\u5217\u957f\u5ea6\u3001\u6c28\u57fa\u9178\u7ec4\u6210\u3001\u758f\u6c34\u6027\u53ca\u7279\u6b8a\u4fee\u9970\u7b49\u56e0\u7d20\u5bc6\u5207\u76f8\u5173\u3002\u5e38\u89c1\u7684\u7eaf\u5316\u65b9\u6cd5\u5305\u62ec\u53cd\u76f8\u9ad8\u6548\u6db2\u76f8\u8272\u8c31\uff08RP-HPLC\uff09\uff0c\u5e76\u901a\u5e38\u7ed3\u5408\u8d28\u8c31\uff08MS\uff09\u8fdb\u884c\u5206\u5b50\u91cf\u786e\u8ba4\uff0c\u4ece\u800c\u8bc4\u4f30\u4ea7\u54c1\u7684\u7eaf\u5ea6\u548c\u76ee\u6807\u5206\u5b50\u4fe1\u606f\u3002\u5bf9\u4e8e\u73af\u80bd\u3001\u78f7\u9178\u5316\u591a\u80bd\u53ca\u8367\u5149\u6807\u8bb0\u591a\u80bd\u7b49\u7279\u6b8a\u4ea7\u54c1\uff0c\u8fd8\u9700\u8981\u6839\u636e\u5177\u4f53\u7ed3\u6784\u5236\u5b9a\u76f8\u5e94\u7684\u5408\u6210\u4e0e\u68c0\u6d4b\u65b9\u6848\u3002<\/p>

\u591a\u80bd\u5728\u79d1\u7814\u9886\u57df\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u4ef7\u503c\u3002\u5728\u57fa\u7840\u751f\u547d\u79d1\u5b66\u7814\u7a76\u4e2d\uff0c\u53ef\u7528\u4e8e\u86cb\u767d\u8d28\u529f\u80fd\u5206\u6790\u3001\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u53ca\u7ec6\u80de\u4fe1\u53f7\u7814\u7a76\uff1b\u5728\u514d\u75ab\u5b66\u7814\u7a76\u4e2d\uff0c\u53ef\u7528\u4e8e\u6297\u539f\u8868\u4f4d\u548c\u6297\u4f53\u8bc6\u522b\u5206\u6790\uff1b\u5728\u836f\u7269\u7814\u53d1\u9886\u57df\uff0c\u53ef\u7528\u4e8e\u5019\u9009\u5206\u5b50\u7b5b\u9009\u53ca\u6784\u6548\u5173\u7cfb\u7814\u7a76\u3002\u6b64\u5916\uff0c\u8367\u5149\u6807\u8bb0\u591a\u80bd\u4e5f\u5e7f\u6cdb\u5e94\u7528\u4e8e\u7ec6\u80de\u6210\u50cf\u3001\u5206\u5b50\u793a\u8e2a\u53ca\u751f\u7269\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u7814\u7a76\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u968f\u7740\u79d1\u7814\u9700\u6c42\u4e0d\u65ad\u7ec6\u5316\uff0c\u591a\u80bd\u5408\u6210\u6b63\u5411\u66f4\u9ad8\u8d28\u91cf\u3001\u66f4\u591a\u6837\u5316\u7684\u7ed3\u6784\u4fee\u9970\u53ca\u4e2a\u6027\u5316\u5b9a\u5236\u65b9\u5411\u53d1\u5c55\u3002\u81ea\u52a8\u5316\u5408\u6210\u8bbe\u5907\u3001\u7eaf\u5316\u6280\u672f\u548c\u5206\u6790\u68c0\u6d4b\u65b9\u6cd5\u7684\u8fdb\u6b65\uff0c\u4e5f\u4e3a\u590d\u6742\u591a\u80bd\u7684\u5236\u5907\u63d0\u4f9b\u4e86\u66f4\u591a\u53ef\u80fd\u3002\u73af\u80bd\u3001\u8102\u80bd\u53ca\u5404\u79cd\u529f\u80fd\u6027\u4fee\u9970\u591a\u80bd\uff0c\u6b63\u5728\u6210\u4e3a\u751f\u547d\u79d1\u5b66\u7814\u7a76\u4e2d\u7684\u91cd\u8981\u65b9\u5411\u3002<\/p>

\u6469\u5c14\u751f\u7269\u4e13\u6ce8\u4e8e\u591a\u80bd\u5b9a\u5236\u9700\u6c42\u4e0e\u79d1\u7814\u9879\u76ee\u670d\u52a1\uff0c\u9762\u5411\u9ad8\u6821\u5b9e\u9a8c\u5ba4\u3001\u79d1\u7814\u9662\u6240\u53ca\u751f\u7269\u6280\u672f\u4f01\u4e1a\uff0c\u63d0\u4f9b\u5e38\u89c4\u591a\u80bd\u3001\u4fee\u9970\u591a\u80bd\u3001\u73af\u80bd\u53ca\u8367\u5149\u6807\u8bb0\u591a\u80bd\u7b49\u5b9a\u5236\u670d\u52a1\u652f\u6301\u3002\u6211\u4eec\u91cd\u89c6\u6bcf\u4e00\u4e2a\u9879\u76ee\u7684\u5e8f\u5217\u3001\u7eaf\u5ea6\u3001\u4fee\u9970\u53ca\u7528\u91cf\u8981\u6c42\uff0c\u81f4\u529b\u4e8e\u901a\u8fc7\u4e13\u4e1a\u7684\u6280\u672f\u6c9f\u901a\u4e0e\u9879\u76ee\u534f\u8c03\uff0c\u4e3a\u79d1\u7814\u5ba2\u6237\u63d0\u4f9b\u5408\u9002\u7684\u591a\u80bd\u5b9a\u5236\u65b9\u6848\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u5e38\u89c4\u591a\u80bd\u5408\u6210\u4e3b\u8981\u91c7\u7528\u56fa\u76f8\u591a\u80bd\u5408\u6210\u6cd5\uff08SPPS\uff09\u3002\u8be5\u65b9\u6cd5\u4ee5\u6811\u8102\u4e3a\u8f7d\u4f53\uff0c\u6309\u7167\u9884\u5b9a\u7684\u6c28\u57fa\u9178\u5e8f\u5217\uff0c\u901a\u8fc7\u53cd\u590d\u8fdb\u884c\u8131\u4fdd\u62a4\u548c\u6c28\u57fa\u9178\u5076\u8054\u53cd\u5e94\uff0c\u9010\u6b65\u5ef6\u957f\u80bd\u94fe\u3002\u5b8c\u6210\u5408\u6210\u540e\uff0c\u7ecf\u8fc7\u5207\u5272\u3001\u8131\u4fdd\u62a4\u3001\u7c97\u54c1\u5904\u7406\u53ca\u9ad8\u6548\u6db2\u76f8\u8272\u8c31\uff08HPLC\uff09\u7eaf\u5316\uff0c\u83b7\u5f97\u76ee\u6807\u591a\u80bd\u3002\u6700\u540e\u901a\u8fc7\u8d28\u8c31\uff08MS\uff09\u8fdb\u884c\u5206\u5b50\u91cf\u786e\u8ba4\uff0c\u5e76\u7ed3\u5408HPLC\u5206\u6790\u4ea7\u54c1\u7eaf\u5ea6\uff0c\u786e\u4fdd\u5176\u7b26\u5408\u7ea6\u5b9a\u7684\u8d28\u91cf\u8981\u6c42\u3002\u8be5\u65b9\u6cd5\u5177\u6709\u64cd\u4f5c\u7075\u6d3b\u3001\u9002\u7528\u8303\u56f4\u5e7f\u7b49\u7279\u70b9\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8e\u751f\u547d\u79d1\u5b66\u53ca\u751f\u7269\u533b\u5b66\u7814\u7a76\u3002<\/p> <\/div>\n\n <\/div>\n\n <\/div>\n\n \n

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\n \n \n \u591a\u80bd\u7684\u4ef7\u683c\u7ec4\u6210\uff1f<\/span>\n\n \n
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\n \n\t\t\t\t\t\t\t\t\t\t<\/i> <\/div>\n\n
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\u591a\u80bd\u5b9a\u5236\u4ef7\u683c\u901a\u5e38\u7531\u5408\u6210\u96be\u5ea6\u3001\u6c28\u57fa\u9178\u6570\u91cf\u3001\u76ee\u6807\u7eaf\u5ea6\u3001\u8ba2\u5355\u6570\u91cf\u53ca\u7279\u6b8a\u4fee\u9970\u8981\u6c42\u7b49\u56e0\u7d20\u5171\u540c\u51b3\u5b9a\u3002\u4e00\u822c\u800c\u8a00\uff0c\u5e8f\u5217\u8d8a\u957f\u3001\u7ed3\u6784\u8d8a\u590d\u6742\uff0c\u5408\u6210\u6210\u672c\u8d8a\u9ad8\uff1b\u7eaf\u5ea6\u8981\u6c42\u8d8a\u9ad8\uff0c\u6240\u9700\u7684\u7eaf\u5316\u5de5\u827a\u548c\u68c0\u6d4b\u6210\u672c\u4e5f\u4f1a\u76f8\u5e94\u589e\u52a0\u3002\u6b64\u5916\uff0c\u8367\u5149\u6807\u8bb0\u3001\u73af\u5316\u3001\u78f7\u9178\u5316\u7b49\u7279\u6b8a\u4fee\u9970\u4e5f\u4f1a\u5f71\u54cd\u6700\u7ec8\u62a5\u4ef7\u3002\u4ea7\u54c1\u4ef7\u683c\u901a\u5e38\u8fd8\u5305\u542b\u539f\u6750\u6599\u3001\u5408\u6210\u3001\u7eaf\u5316\u3001\u8d28\u91cf\u68c0\u6d4b\u3001\u5206\u88c5\u53ca\u5305\u88c5\u7b49\u8d39\u7528\u3002\u56e0\u6b64\uff0c\u51c6\u786e\u62a5\u4ef7\u9700\u8981\u7ed3\u5408\u5177\u4f53\u5e8f\u5217\u548c\u6280\u672f\u8981\u6c42\u8fdb\u884c\u7efc\u5408\u8bc4\u4f30\u3002<\/p> <\/div>\n\n <\/div>\n\n <\/div>\n\n \n

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\n \n \n \u6469\u5c14\u751f\u7269\u7684\u4f18\u52bf\uff1f<\/span>\n\n \n
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\n \n\t\t\t\t\t\t\t\t\t\t<\/i> <\/div>\n\n
\n \n\t\t\t\t\t\t\t\t\t\t<\/i> <\/div>\n <\/div>\n\n \n <\/a>\n <\/div>\n\n
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